ᱠᱟᱯᱷᱤᱱ ᱯᱟᱞᱴᱟᱣ ᱚᱠᱛ ᱛᱤᱵᱨᱟᱭᱟ?

ᱵᱟᱹᱲᱛᱤ ᱠᱟᱹᱢᱤ ᱯᱩᱱᱨᱤᱵᱷᱤᱠᱷᱟ ᱦᱩᱥᱤᱭᱟᱹᱨᱤ, ᱧᱮᱞ ᱫᱷᱟᱹᱲᱤᱡ ᱟᱨ ᱢᱚᱱ ᱫᱮᱱ ᱨᱮ ᱞᱚᱜᱽᱵᱷᱟᱜ ᱢᱤᱫ ᱞᱮᱠᱟ ᱯᱷᱚᱞ ᱟᱨ ᱦᱤᱭᱟᱹᱞ ᱟᱨ ᱩᱪᱪᱚ-ᱛᱟᱦᱚᱞ ᱪᱤᱱᱛᱟᱹ ᱠᱟᱹᱢᱤ ᱨᱮ ᱵᱷᱮᱜᱟᱨ-ᱵᱷᱮᱜᱟᱨ ᱯᱷᱚᱞ ᱵᱤᱵᱨᱚᱬ ᱠᱮᱫᱟ᱾ ᱚᱱᱟ ᱞᱟᱹᱜᱤᱫ, ᱢᱤᱫ ᱟᱹᱞᱜᱟ ᱡᱚᱵᱟᱵ ᱛᱤᱵᱨᱟᱭᱟ ᱢᱮᱱᱛᱮ ᱛᱷᱟᱹᱣᱠᱟᱹ ᱪᱤᱱᱛᱟᱹ ᱨᱮ ᱥᱟᱱᱟᱢ ᱯᱟᱹᱨᱤᱥ ᱵᱷᱟᱞᱮᱱᱟ ᱢᱮᱱᱛᱮ ᱵᱟᱭ ᱵᱚᱞᱚᱜᱼᱟ᱾ ᱢᱚᱱ ᱫᱮᱱ ᱵᱟᱵᱚᱛ ᱯᱩᱱᱨᱤᱵᱷᱤᱠᱷᱟ ᱦᱚ ᱵᱷᱮᱜᱟᱨ-ᱵᱷᱮᱜᱟᱨ ᱠᱟᱹᱢᱤ, ᱱᱤᱭᱚᱢᱤᱛ ᱵᱮᱵᱷᱚᱦᱟᱨ ᱟᱨ ᱵᱟᱹᱱᱩᱜ ᱵᱮᱵᱷᱚᱦᱟᱨ ᱯᱟᱹᱨᱤᱥ ᱚᱱᱚᱞ ᱠᱮᱫᱟ᱾ McLellan et al., 2016 Einöther et al., 2012

ᱢᱩᱬ ᱢᱟᱹᱱᱮ ᱛᱟᱦᱮᱸᱱ ᱛᱟᱦᱮᱸᱱᱟ

ᱜᱤᱫᱽᱨᱟᱹ ᱠᱚᱢ ᱧᱟᱢ ᱦᱚᱲ ᱟᱨ ᱡᱚᱛᱚ ᱜᱤᱫᱽᱨᱟᱹ ᱧᱟᱢ ᱦᱚᱲ ᱫᱚ ᱵᱷᱤᱱᱱᱟᱹᱜ ᱠᱟᱱᱟ᱾ ᱜᱤᱫᱽᱨᱟᱹ ᱠᱚᱢ ᱠᱟᱛᱮ ᱜᱚᱵᱷᱮᱥᱚᱱ ᱨᱮ ᱧᱮᱞ ᱫᱷᱟᱹᱲᱤᱡ ᱠᱷᱚᱛᱤ ᱦᱚᱯᱚᱱ ᱦᱚᱭᱮᱫᱼᱟ, ᱟᱨ ᱡᱚᱛᱚ ᱜᱤᱫᱽᱨᱟᱹ ᱵᱟᱹᱱᱩᱜ ᱨᱮ ᱢᱮᱴᱟ-ᱮᱱᱟᱞᱤᱥᱤᱥ ᱫᱚ ᱵᱩᱫᱷᱤ ᱠᱟᱹᱢᱤ ᱯᱟᱹᱨᱤᱥ ᱥᱟᱱᱟᱢ ᱢᱤᱫ ᱞᱮᱠᱟ ᱯᱨᱚᱵᱷᱟᱵᱤᱛ ᱵᱟᱭ ᱦᱚᱭᱟ᱾ ᱜᱤᱫᱽᱨᱟᱹ-ᱨᱤᱠᱟᱹ ᱢᱟᱹᱱᱮ ᱨᱮ ᱥᱴᱤᱢᱩᱞᱮᱱᱴ ᱨᱮᱭᱟᱜ ᱯᱷᱚᱞ ᱫᱚ ᱜᱤᱫᱽᱨᱟᱹ ᱧᱟᱢ ᱦᱚᱲ ᱨᱮ ᱚᱱᱟᱜ ᱞᱮᱠᱟ ᱞᱟᱵᱷ ᱢᱮᱱᱛᱮ ᱟᱹᱨᱤᱥ ᱵᱟᱝ ᱦᱚᱭᱟ᱾ Van Dongen et al., 2003 Lim et al., 2010

ᱧᱮᱞ ᱫᱷᱟᱹᱲᱤᱡ ᱯᱷᱚᱞ ᱦᱚ ᱵᱷᱮᱜᱟᱨ ᱦᱚᱭᱟ᱾ ᱞᱮᱵᱚᱨᱮᱴᱚᱨᱤ ᱜᱚᱵᱷᱮᱥᱚᱱ ᱨᱮ ᱫᱷᱤᱨᱤ ᱡᱚᱵᱟᱵ ᱢᱤᱫ ᱠᱷᱚᱱ ᱵᱟᱹᱲᱛᱤ ᱚᱠᱛ, ᱡᱚᱵᱟᱵ ᱛᱤᱵᱨᱟ ᱟᱨ ᱠᱟᱹᱢᱤ ᱚᱠᱛ ᱢᱟᱯ ᱦᱚᱭᱟ; ᱢᱤᱫ ᱠᱷᱟᱴᱚ ᱠᱷᱮᱞ ᱫᱚ ᱢᱩᱲᱩᱫ ᱵᱟᱝ ᱥᱟᱱᱟᱢ ᱠᱷᱚᱱ ᱛᱤᱵᱨᱟ ᱡᱚᱵᱟᱵ ᱧᱮᱞᱟ᱾ Basner ᱟᱨ Dinges ᱫᱮᱠᱷᱟᱣ ᱠᱮᱫᱟᱠᱤ ᱯᱷᱚᱞ ᱵᱟᱪᱷᱟᱣ ᱯᱷᱟᱹᱨᱤᱥᱟᱹᱣ ᱥᱟᱭᱠᱚᱢᱚᱴᱚᱨ ᱧᱮᱞ ᱫᱷᱟᱹᱲᱤᱡ ᱯᱚᱨᱤᱠᱷᱟ (PVT) ᱜᱤᱫᱽᱨᱟᱹ ᱠᱚᱢ ᱨᱮ ᱠᱚᱛᱷᱟᱣ ᱠᱚ ᱯᱷᱚᱞ ᱵᱟᱫᱽᱞᱟᱣᱟ᱾ Basner et al., 2011

ᱵᱟᱹᱲᱛᱤ ᱢᱟᱛᱨᱟ ᱮᱢ ᱠᱟᱛᱮ ᱟᱨᱦᱚᱸ ᱵᱷᱟᱞᱮᱱᱟ?

ᱢᱚᱱ ᱫᱮᱱ ᱯᱩᱱᱨᱤᱵᱷᱤᱠᱷᱟ ᱫᱚ ᱢᱟᱛᱨᱟ ᱥᱟᱶ ᱡᱩᱲᱟᱹᱣ ᱯᱷᱚᱞ ᱟᱨ ᱱᱤᱭᱚᱢᱤᱛ ᱵᱮᱵᱷᱚᱦᱟᱨ ᱮᱛᱮᱦᱚᱯ ᱵᱟᱵᱚᱛ ᱥᱟᱹᱠᱷᱤ ᱵᱟᱹᱱᱩᱜ ᱢᱮᱱᱛᱮ ᱧᱮᱞ ᱠᱮᱫᱟ᱾ ᱛᱤᱱᱟᱹᱜ ᱜᱚᱵᱷᱮᱥᱚᱱ ᱨᱮ ᱞᱟᱵᱷ ᱧᱮᱞᱮᱱᱟ ᱚᱱᱟ ᱫᱚ ᱱᱤᱡᱮᱨ ᱵᱮᱥᱴ ᱥᱠᱚᱨ ᱧᱟᱢ ᱦᱟᱹᱵᱤᱡ ᱡᱚᱢ ᱵᱟᱹᱲᱛᱤ ᱠᱟᱛᱮ ᱡᱚᱢ ᱢᱮᱱᱛᱮ ᱥᱟᱹᱠᱷᱤ ᱵᱟᱝᱟ᱾ ᱟᱨ ᱚᱱᱟ ᱥᱟᱹᱠᱷᱤ ᱫᱚ ᱩᱢᱨᱮᱨ, ᱡᱟᱹᱛ ᱵᱟᱝ ᱥᱟᱨᱤᱨ ᱢᱟᱯ ᱞᱮᱠᱟ ᱵᱨᱟᱣᱡᱚᱨ ᱯᱚᱨᱤᱠᱷᱟ ᱞᱟᱹᱜᱤᱫ ᱢᱟᱛᱨᱟ ᱪᱟᱨᱴ ᱵᱟᱭ ᱯᱚᱨᱚᱢᱟᱱ ᱮᱫᱟ᱾ Einöther et al., 2012

ᱜᱤᱫᱽᱨᱟᱹ ᱨᱮ ᱠᱚᱢ ᱦᱚᱭᱟ ᱞᱟᱹᱜᱤᱫ ᱦᱤᱥᱟᱹᱵ ᱞᱮᱛᱟᱹᱜ ᱠᱟᱱᱟ

Gardiner ᱟᱨ ᱛᱤᱭᱟᱹᱜ ᱜᱤᱫᱽᱨᱟᱹ ᱮᱢᱟᱱ ᱢᱮᱴᱟ-ᱮᱱᱟᱞᱤᱥᱤᱥ ᱨᱮ ᱠᱟᱯᱷᱤᱱ ᱛᱟᱭᱚᱢ ᱢᱩᱲᱩᱫ ᱜᱤᱫᱽᱨᱟᱹ ᱚᱠᱛ ᱢᱩᱲᱩᱫ 45 ᱴᱤᱯᱤᱡ ᱠᱚᱢ ᱧᱟᱢᱮᱱᱟ᱾ ᱱᱚᱶᱟ ᱨᱮ ᱵᱷᱮᱜᱟᱨ-ᱵᱷᱮᱜᱟᱨ ᱢᱟᱛᱨᱟ, ᱚᱠᱛ ᱟᱨ ᱵᱷᱟᱜᱤ ᱦᱚᱲ ᱡᱚᱢᱟ ᱠᱮᱫᱟ, ᱚᱱᱟᱛᱮ ᱡᱚᱢᱟ ᱢᱩᱫᱽᱫᱚ ᱢᱤᱫ ᱦᱚᱲ ᱨᱮᱭᱟᱜ ᱜᱤᱫᱽᱨᱟᱹ ᱵᱟᱹᱨᱤ ᱨᱮ ᱪᱮᱫ ᱦᱚᱭᱟ ᱚᱱᱟ ᱵᱟᱭ ᱧᱮᱞ ᱠᱟᱛᱷᱟᱭᱟ᱾ ᱱᱚᱶᱟ ᱫᱮᱠᱷᱟᱣ ᱠᱮᱫᱟᱠᱤ ᱞᱚᱜᱽᱵᱷᱟᱜ ᱦᱩᱥᱤᱭᱟᱹᱨᱤ ᱞᱟᱵᱷ ᱫᱚ ᱛᱟᱭᱚᱢ ᱜᱤᱫᱽᱨᱟᱹ ᱥᱟᱶ ᱦᱚᱸ ᱧᱮᱞ ᱛᱮ ᱞᱮᱛᱟᱹᱜ ᱠᱟᱱᱟ᱾ Gardiner et al., 2023

ᱯᱞᱮᱥᱤᱵᱚ ᱥᱟᱶ ᱛᱩᱞᱟᱹᱣ ᱜᱚᱵᱷᱮᱥᱚᱱ ᱨᱮ, 400 mg ᱵᱮᱲᱟᱛᱮ ᱜᱤᱫᱽᱨᱟᱹ ᱚᱠᱛ, ᱜᱤᱫᱽᱨᱟᱹ ᱢᱟᱲᱟᱝ ᱯᱮ ᱴᱟᱹᱲᱤᱡ ᱟᱨ ᱪᱷᱚ ᱴᱟᱹᱲᱤᱡ ᱮᱢ ᱠᱮᱛᱮ ᱜᱤᱫᱽᱨᱟᱹ ᱵᱷᱟᱜᱮᱫ ᱠᱮᱫᱟ᱾ ᱱᱚᱶᱟ ᱫᱚ ᱵᱟᱹᱲᱛᱤ ᱜᱚᱵᱷᱮᱥᱚᱱ ᱢᱟᱛᱨᱟ, ᱡᱚᱢ ᱞᱟᱹᱜᱤᱫ ᱥᱚᱞᱦᱟ ᱵᱟᱝᱟ᱾ ᱪᱷᱚ ᱴᱟᱹᱲᱤᱡ ᱛᱟᱭᱚᱢ ᱯᱷᱚᱞ ᱫᱚ ᱥᱟᱱᱟᱢ ᱦᱚᱲ ᱞᱟᱹᱜᱤᱫ ᱚᱱᱟ ᱛᱟᱭᱚᱢ ᱯᱨᱚᱵᱷᱟᱵ ᱵᱟᱹᱱᱩᱜ ᱢᱮᱱᱛᱮ ᱞᱟᱹᱥᱟᱹ ᱦᱚᱸ ᱵᱟᱭ ᱛᱮᱭᱟᱨ ᱛᱟᱦᱮᱸᱫᱟ᱾ Drake et al., 2013

ᱱᱤᱡᱮᱨ ᱛᱩᱞᱟᱹ ᱫᱚ ᱥᱟᱹᱨᱤ ᱛᱮ ᱪᱮᱫ ᱩᱫᱩᱜ ᱮᱫᱟ?

ᱪᱟ ᱛᱟᱭᱚᱢ ᱢᱤᱫ ᱵᱷᱟᱞ ᱠᱷᱮᱞ ᱨᱮ ᱟᱥᱟ, ᱥᱤᱠᱷᱟᱹᱣ, ᱥᱟᱫᱷᱟᱨᱚᱬ ᱵᱷᱮᱫ, ᱫᱤᱱ ᱚᱠᱛ ᱟᱨ ᱠᱟᱯᱷᱤᱱ ᱵᱮᱵᱷᱚᱦᱟᱨ ᱡᱚᱢᱟ ᱢᱮᱥᱟ ᱠᱟᱱᱟ᱾ ᱢᱚᱱ ᱫᱮᱱ ᱯᱩᱱᱨᱤᱵᱷᱤᱠᱷᱟ ᱨᱮ ᱱᱤᱭᱚᱱᱛᱨᱤᱛ ᱛᱩᱞᱟᱹ ᱨᱮ ᱜᱩᱨᱩᱛᱚᱢ ᱟᱨ ᱵᱟᱹᱨᱤ ᱵᱟᱹᱱᱩᱜ ᱢᱟᱲᱟᱝ-ᱛᱟᱭᱚᱢ ᱠᱷᱮᱞ ᱨᱮ ᱚᱠᱟ ᱫᱚ ᱚᱥᱟᱹᱨ ᱯᱷᱚᱞ ᱵᱟᱭ ᱪᱷᱟᱸᱴᱟᱣ ᱟ᱾ ᱟᱹᱲᱤ ᱠᱷᱮᱞ ᱠᱚᱠᱟᱛᱮ ᱥᱟᱱᱟᱢ ᱠᱷᱚᱱ ᱵᱷᱟᱞ ᱯᱷᱚᱞ ᱵᱟᱪᱷᱟᱣ ᱮᱫ ᱠᱟᱛᱮ ᱚᱱᱟ ᱠᱟᱯᱷᱤᱱ ᱨᱮᱭᱟᱜ ᱯᱷᱚᱞ ᱥᱟᱹᱠᱷᱤ ᱟᱨ ᱠᱚᱢ ᱟᱠᱟᱱᱟ᱾ Einöther et al., 2012

ᱡᱩᱫᱤ ᱟᱢ ᱢᱟᱹᱲᱤᱡ ᱠᱟᱯᱷᱤᱱ ᱡᱚᱢᱟᱢ, ᱛᱷᱟᱯᱚᱱ ᱡᱚᱢ ᱟᱨ ᱜᱤᱫᱽᱨᱟᱹ ᱥᱟᱶ ᱢᱤᱫ ᱞᱮᱠᱟ ᱚᱱᱟᱹ ᱚᱠᱛ ᱨᱮ ᱠᱟᱹᱢᱤ ᱠᱮᱛᱮ ᱵᱟᱹᱛᱟᱹᱣ ᱫᱚ ᱢᱤᱫ ᱚᱱᱤᱭᱟᱹ ᱧᱮᱞ ᱦᱚᱭ ᱫᱟᱲᱮᱟ᱾ ᱱᱚᱶᱟ ᱫᱚ ᱠᱟᱯᱷᱤᱱ ᱮᱦᱚᱯ ᱢᱮ, ᱢᱟᱛᱨᱟ ᱵᱟᱹᱲᱛᱤ ᱢᱮ, ᱟᱨ ᱯᱚᱨᱤᱠᱷᱟ ᱞᱟᱹᱜᱤᱫ ᱡᱚᱛᱚ ᱱᱤᱫᱽᱨᱟ ᱠᱚᱢ ᱢᱮ ᱢᱮᱱᱛᱮ ᱢᱚᱛᱞᱚᱵ ᱵᱟᱝᱟ᱾ ᱵᱟᱹᱲᱛᱤ ᱵᱟᱹᱲᱛᱤ ᱱᱤᱫᱽᱨᱟ ᱠᱟᱹᱢᱤ ᱥᱚᱞᱦᱟ ᱮᱫᱟ; ᱠᱟᱯᱷᱤᱱ ᱜᱚᱵᱷᱮᱥᱚᱱ ᱫᱚ ᱥᱴᱤᱢᱩᱞᱮᱴ ᱱᱤᱫᱽᱨᱟ ᱟᱵᱟᱹᱛ ᱮᱫᱟ ᱢᱮᱱᱛᱮ ᱵᱟᱭ ᱯᱚᱨᱚᱢᱟᱱ ᱮᱫᱟ᱾ Watson et al., 2015 Van Dongen et al., 2003

ᱥᱟᱹᱨᱤ ᱯᱷᱚᱞ ᱫᱚ ᱟᱹᱲᱤ ᱠᱷᱟᱴᱚ: ᱠᱟᱯᱷᱤᱱ ᱢᱤᱫ ᱠᱷᱟᱥ ᱦᱟᱞᱚᱛ ᱨᱮ ᱢᱚᱱ-ᱫᱮᱱ ᱠᱟᱹᱢᱤ ᱯᱷᱚᱞ ᱨᱮ ᱚᱥᱟᱹᱨ ᱮᱫᱟ, ᱢᱮᱱᱛᱮ ᱡᱟᱹᱴᱤᱞ ᱪᱤᱱᱛᱟᱹ ᱟᱨ ᱛᱟᱭᱚᱢ ᱜᱤᱫᱽᱨᱟᱹ ᱯᱷᱚᱞ ᱟᱹᱞᱜᱟ ᱞᱮᱛᱟᱹᱜ ᱠᱟᱱᱟ᱾ ᱚᱠᱟ ᱜᱚᱵᱷᱮᱥᱚᱱ ᱦᱚᱸ ᱵᱟᱭ ᱯᱚᱨᱚᱢᱟᱱ ᱮᱫᱟ ᱠᱤ ᱠᱟᱯᱷᱤᱱ ᱵᱟᱝ ᱠᱷᱮᱞ ᱟᱢᱟᱜ ᱥᱟᱱᱟᱢ ᱵᱩᱫᱷᱤ ᱛᱤᱵᱨᱟ ᱠᱟᱫᱟ᱾ McLellan et al., 2016 Gardiner et al., 2023