ꯀꯦꯐꯤꯟꯅ ꯄꯥꯎꯈꯨꯝ ꯄꯨꯡ ꯑꯣꯏꯕ ꯍꯟꯊꯍꯜꯂꯤꯕ꯭ꯔꯥ?

ꯊꯕꯛ ꯇꯧꯕꯒꯤ ꯑꯐꯕ ꯔꯤꯚꯤꯌꯨꯅꯅ ꯑꯀꯣꯌꯕ ꯊꯥꯒꯠꯄ, ꯌꯦꯡꯁꯤꯟꯕ ꯑꯃꯁꯨꯡ ꯊꯤꯅꯕꯗꯥ ꯑꯆꯨꯝꯕ ꯑꯐꯕ ꯑꯃꯁꯨꯡ ꯃꯔꯣꯜ ꯊꯤꯅꯕ ꯑꯃꯁꯨꯡ ꯑꯍꯦꯟꯕ ꯊꯤꯅꯕꯒꯤ ꯊꯕꯛꯁꯤꯡꯗꯥ ꯑꯐꯕ ꯃꯔꯝ ꯑꯃꯗꯥ ꯑꯃꯨꯛꯇꯥ ꯑꯣꯏꯗꯦ꯫ ꯃꯔꯣꯜ ꯄꯤꯕ ꯁꯥꯡꯅꯕ ꯑꯃꯅ ꯊꯤꯅꯕꯒꯤ ꯄꯨꯝꯅꯃꯛ ꯑꯐꯕ ꯑꯣꯏꯈ꯭ꯔꯦ ꯍꯥꯌꯕ ꯑꯔꯊ ꯅꯠꯇꯦ꯫ ꯊꯤꯅꯕꯒꯤ ꯔꯤꯚꯤꯌꯨꯅꯅ ꯊꯕꯛꯀꯤ ꯃꯈꯜ, ꯃꯍꯧꯁꯥꯒꯤ ꯂꯧꯕ ꯑꯃꯁꯨꯡ ꯂꯧꯗꯕꯗꯒꯤ ꯍꯣꯡꯕꯁꯤꯡꯒꯤ ꯈꯦꯠꯅꯕꯁꯨ ꯌꯦꯡꯂꯤ꯫ McLellan et al., 2016 Einöther et al., 2012

ꯃꯃꯥꯡꯒꯤ ꯑꯃꯣꯠ ꯃꯔꯨ ꯀꯔꯤꯒꯤ ꯃꯔꯨꯑꯣꯏꯕꯒꯦ

ꯅꯤꯠꯇꯕ ꯍꯟꯊꯕ ꯑꯃꯁꯨꯡ ꯑꯐꯕ ꯅꯤꯠꯇꯕ ꯈꯦꯠꯅꯩ꯫ ꯅꯤꯠꯇꯕ ꯍꯟꯊꯕꯒꯤ ꯄꯔꯤꯛꯁꯥꯁꯤꯡꯅ ꯊꯤꯅꯕꯗꯥ ꯃꯊꯝ ꯃꯊꯝꯗꯥ ꯑꯐꯕ ꯍꯟꯊꯩ ꯍꯥꯌꯕ ꯎꯠꯂꯤ, ꯑꯃꯁꯨꯡ ꯅꯤꯠꯇꯕ ꯃꯊꯣꯜ ꯄꯨꯝꯅꯃꯛꯅ ꯈꯦꯠꯅꯕ ꯑꯃꯗꯥ ꯑꯣꯏꯗꯦ ꯍꯥꯌꯕ ꯃꯦꯇꯥ-ꯑꯦꯅꯦꯂꯤꯁꯤꯁꯅ ꯎꯠꯂꯤ꯫ ꯃꯤꯑꯣꯏ ꯅꯤꯠꯇꯕ ꯃꯃꯥꯡꯗꯥ ꯂꯩꯕ ꯃꯇꯝꯗꯥ ꯊꯤꯅꯕꯒꯤ ꯊꯕꯛꯇꯥ ꯀꯦꯐꯤꯟꯅ ꯀꯔꯤ ꯑꯣꯏ ꯍꯥꯌꯕ ꯑꯗꯨ ꯅꯤꯠꯇꯕ ꯅꯠꯇꯕ ꯃꯤꯑꯣꯏꯗꯥ ꯑꯃꯨꯛꯇꯥ ꯑꯣꯏꯕ ꯂꯧꯁꯤꯟꯕ ꯌꯥꯗꯦ꯫ Van Dongen et al., 2003 Lim et al., 2010

ꯌꯦꯡꯁꯤꯟꯕ ꯃꯁꯛꯁꯤꯡꯁꯨ ꯈꯦꯠꯅꯩ꯫ ꯂꯦꯕꯣꯔꯦꯇꯣꯔꯤꯗꯥ ꯑꯄꯥꯟꯕ ꯄꯥꯎꯈꯨꯝꯁꯤꯡ, ꯄꯥꯎꯈꯨꯝ ꯁꯦꯡꯕ ꯑꯃꯁꯨꯡ ꯊꯕꯛꯇꯥ ꯂꯥꯏꯕ ꯃꯇꯝ ꯃꯥꯄꯤꯕ ꯌꯥꯏ; ꯆꯨꯔꯥꯛ ꯒꯦꯝ ꯑꯃꯅ ꯑꯦꯕꯔꯦꯖ ꯅꯠꯇ꯭ꯔꯒ ꯑꯇꯤ ꯐꯕ ꯄꯥꯎꯈꯨꯝ ꯊꯤꯕ ꯌꯥꯏ꯫ Basner ꯑꯃꯁꯨꯡ Dinges ꯅ ꯄꯔꯤꯛꯁꯥꯒꯤ ꯃꯈꯜ ꯈꯅꯕꯅ ꯅꯤꯠꯇꯕꯅ ꯄꯥꯎꯈꯨꯝ ꯊꯤꯕ ꯄꯔꯤꯛꯁꯥꯒꯤ ꯑꯐꯕ ꯃꯁꯛꯇꯥ ꯀꯔꯤ ꯃꯥꯡꯍꯅꯤ ꯍꯥꯌꯕ ꯎꯠꯂꯤ꯫ Basner et al., 2011

ꯃꯁꯛ ꯍꯦꯟꯅ ꯂꯧꯕꯅ ꯑꯐꯕ ꯍꯦꯟꯅ ꯐꯪꯍꯜꯂꯤꯕ꯭ꯔꯥ?

ꯊꯤꯅꯕꯒꯤ ꯔꯤꯚꯤꯌꯨꯅꯅ ꯃꯁꯛꯅ ꯑꯐꯕ ꯈꯦꯠꯅꯕ ꯑꯃꯁꯨꯡ ꯃꯍꯧꯁꯥꯒꯤ ꯂꯧꯕꯒꯤ ꯃꯁꯛꯅ ꯀꯔꯤ ꯑꯣꯏ ꯍꯥꯌꯕꯗꯥ ꯑꯆꯨꯝꯕ ꯄꯥꯎ ꯂꯩꯇꯦ ꯍꯥꯌꯕ ꯈꯪꯍꯜꯂꯤ꯫ ꯄꯔꯤꯛꯁꯥ ꯀꯌꯥꯗꯥ ꯑꯐꯕ ꯐꯪꯕ ꯎꯕ ꯑꯁꯤ ꯅꯪꯅ ꯑꯐꯕ ꯑꯇꯤ ꯑꯃꯥ ꯐꯪꯗ꯭ꯔꯤꯕ ꯃꯊꯝꯗꯥ ꯂꯥꯛꯅꯕ ꯃꯁꯛ ꯍꯦꯟꯅ ꯂꯧꯕꯒꯤ ꯄꯥꯎ ꯅꯠꯇꯦ꯫ ꯑꯃꯁꯨꯡ ꯃꯤꯑꯣꯏꯒꯤ ꯆꯍꯤ, ꯅꯨꯄꯤ-ꯅꯨꯄꯥ ꯅꯠꯇ꯭ꯔꯒ ꯀꯥꯌꯕꯤꯗꯥ ꯅꯤꯟꯕ ꯕ꯭ꯔꯥꯎꯖꯔ ꯄꯔꯤꯛꯁꯥꯒꯤ ꯃꯁꯛ ꯆꯦꯛꯂꯤ ꯍꯥꯌꯕꯁꯨ ꯄꯥꯎ ꯂꯩꯇꯦ꯫ Einöther et al., 2012

ꯅꯤꯠꯇꯕꯒꯤ ꯃꯔꯝ ꯑꯗꯨ ꯂꯧꯕ ꯃꯊꯧ ꯇꯥꯏ

Gardiner ꯑꯃꯁꯨꯡ ꯃꯤꯁꯤꯡꯒꯤ ꯅꯤꯠꯇꯕ ꯃꯦꯇꯥ-ꯑꯦꯅꯦꯂꯤꯁꯤꯁꯅ ꯀꯦꯐꯤꯟ ꯂꯧꯔꯕ ꯃꯇꯨꯡꯗꯥ ꯅꯤꯠꯇꯕꯒꯤ ꯃꯇꯝ ꯑꯦꯕꯔꯦꯖ 45 ꯃꯤꯅꯤꯠ ꯍꯟꯊꯩ ꯍꯥꯌꯕ ꯎꯠꯂꯤ꯫ ꯃꯁꯤꯅ ꯃꯁꯛ, ꯃꯇꯝ ꯑꯃꯁꯨꯡ ꯄꯔꯤꯛꯁꯥ ꯇꯧꯕ ꯃꯤꯑꯣꯏꯁꯤꯡ ꯈꯦꯠꯅꯕꯁꯤꯡ ꯄꯨꯟꯁꯤꯟꯂꯦ; ꯃꯔꯝꯅ ꯑꯦꯕꯔꯦꯖ ꯑꯁꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯒꯤ ꯅꯤꯠꯇꯕ ꯃꯇꯝ ꯑꯃꯒꯤ ꯑꯆꯨꯝꯕ ꯃꯥꯟꯅꯕ ꯅꯠꯇꯦ꯫ ꯑꯁꯤꯅ ꯑꯀꯣꯌꯕ ꯊꯥꯒꯠꯄꯒꯤ ꯃꯇꯨꯡꯗꯥ ꯅꯤꯠꯇꯕ ꯑꯐꯕ ꯑꯗꯨ ꯃꯈꯥ ꯊꯥꯕ ꯅꯤꯠꯇꯕꯒꯤ ꯃꯇꯨꯡ ꯂꯣꯏꯅꯅ ꯌꯦꯡꯕ ꯃꯊꯧ ꯇꯥꯏ꯫ Gardiner et al., 2023

ꯄ꯭ꯂꯦꯁꯤꯕꯣ ꯀꯟꯠꯔꯣꯜ ꯄꯔꯤꯛꯁꯥ ꯑꯃꯗꯥ, ꯅꯤꯠꯇꯕꯒꯤ ꯃꯇꯝꯗꯥ, ꯅꯤꯠꯇꯕꯗꯒꯤ 3 ꯑꯃꯁꯨꯡ 6 ꯑꯥꯏꯟꯗꯥ ꯃꯃꯥꯡꯗ ꯄꯤꯈꯤꯕ 400 mg ꯅ ꯅꯤꯠꯇꯕ ꯂꯥꯡꯊꯣꯛꯈꯤ꯫ ꯃꯁꯤ ꯄꯔꯤꯛꯁꯥꯒꯤ ꯑꯍꯦꯟꯕ ꯃꯁꯛꯅꯤ, ꯂꯧꯕ ꯌꯥꯕ ꯃꯁꯛ ꯍꯥꯌꯕ ꯄꯥꯎ ꯅꯠꯇꯦ꯫ ꯑꯁꯤꯒꯤ 6 ꯑꯥꯏꯟ ꯃꯊꯪꯗꯥ ꯄꯨꯝꯅꯃꯛꯅ ꯑꯐꯕ ꯑꯣꯏꯕ ꯍꯥꯌꯕꯗꯥ ꯑꯃꯨꯛꯇꯥ ꯑꯔꯊ ꯂꯧꯗꯕ ꯃꯊꯧ ꯇꯥꯏ꯫ Drake et al., 2013

ꯅꯪꯅ ꯑꯈꯟꯅ ꯌꯦꯝꯅꯕ ꯑꯃꯗꯒꯤ ꯀꯔꯤ ꯈꯪꯕ ꯌꯥꯒꯅꯤ?

ꯀꯥꯐꯤ ꯃꯇꯨꯡꯗꯥ ꯑꯃꯥ ꯑꯐꯕ ꯑꯣꯏꯈꯤꯕ ꯑꯃꯈꯛ ꯌꯦꯡꯕꯅ ꯊꯥꯖꯕ, ꯊꯕꯛ ꯈꯪꯕ, ꯃꯍꯧꯁꯥꯒꯤ ꯈꯦꯠꯅꯕ, ꯅꯨꯃꯤꯠꯀꯤ ꯃꯇꯝ ꯑꯃꯁꯨꯡ ꯀꯦꯐꯤꯟ ꯂꯧꯕ ꯄꯨꯝꯅꯃꯛ ꯃꯤꯁꯤꯟꯂꯤ꯫ ꯊꯤꯅꯕꯒꯤ ꯔꯤꯚꯤꯌꯨꯅꯅ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯕ ꯑꯈꯟꯅ ꯌꯦꯝꯅꯕꯁꯤꯡꯒꯤ ꯃꯔꯨꯑꯣꯏꯕ ꯎꯠꯂꯤ: ꯀꯟꯠꯔꯣꯜ ꯅꯠꯇꯕ ꯃꯃꯥꯡ-ꯃꯇꯨꯡ ꯒꯦꯝ ꯌꯦꯝꯅꯕꯅ ꯀꯦꯐꯤꯟꯒꯤ ꯑꯐꯤꯕ ꯃꯄꯨꯡ ꯑꯃꯈꯛ ꯈꯪꯍꯜꯂꯗꯦ꯫ ꯌꯦꯝꯅꯕꯒꯤ ꯑꯇꯤ ꯑꯐꯕ ꯑꯃꯈꯛ ꯈꯅꯕꯅ ꯑꯔꯊ ꯑꯗꯨ ꯑꯍꯦꯟꯅ ꯍꯟꯊꯍꯜꯂꯤ꯫ Einöther et al., 2012

ꯅꯪ ꯀꯦꯐꯤꯟ ꯂꯧꯔꯕꯗꯤ, ꯃꯍꯧꯁꯥꯒꯤ ꯂꯧꯕ ꯃꯁꯛ ꯑꯃꯁꯨꯡ ꯅꯤꯠꯇꯕ ꯑꯇꯤ ꯃꯥꯟꯅꯕ ꯌꯦꯝꯅꯕ ꯑꯃꯒꯤ ꯃꯈꯥꯗꯥ ꯂꯤꯄꯤꯟꯕ ꯑꯁꯤ ꯃꯍꯧꯁꯥ ꯑꯣꯏꯅ ꯌꯦꯡꯕ ꯑꯃꯈꯛꯅꯤ꯫ ꯀꯦꯐꯤꯟ ꯍꯧꯕ, ꯃꯁꯛ ꯍꯦꯟꯅ ꯂꯧꯕ ꯅꯠꯇ꯭ꯔꯒ ꯄꯔꯤꯛꯁꯥꯒꯤ ꯃꯇꯝꯗꯥ ꯅꯤꯠꯇꯕ ꯃꯥꯡꯍꯅꯕꯒꯤ ꯃꯔꯝ ꯅꯠꯇꯦ꯫ ꯑꯔꯣꯏꯕ ꯑꯃꯁꯨꯡ ꯃꯍꯧꯁꯥꯒꯤ ꯅꯤꯠꯇꯕ ꯑꯐꯕꯒꯤ ꯀꯟꯁꯦꯟꯁꯁꯅ ꯃꯊꯝ ꯑꯃꯗꯥ ꯃꯄꯨꯡꯐꯥꯕ ꯅꯤꯠꯇꯕ ꯂꯩꯍꯟꯕ ꯍꯥꯌꯅꯩ; ꯀꯦꯐꯤꯟꯒꯤ ꯄꯔꯤꯛꯁꯥꯅ ꯑꯀꯣꯌꯕ ꯄꯤꯕꯅ ꯅꯤꯠꯇꯕ ꯃꯊꯧ ꯅꯠꯇꯦ ꯍꯥꯌꯅ ꯂꯧꯁꯤꯟꯗꯦ꯫ Watson et al., 2015 Van Dongen et al., 2003

ꯑꯆꯨꯝꯕ ꯂꯧꯕ ꯃꯃꯥꯟꯅ ꯑꯈꯟꯅ ꯑꯃꯈꯛꯇꯅꯤ: ꯀꯦꯐꯤꯟꯅ ꯑꯈꯟꯕ ꯃꯊꯣꯜꯁꯤꯡꯗꯥ ꯊꯤꯅꯕꯒꯤ ꯊꯕꯛꯇꯥ ꯀꯔꯤ ꯑꯣꯏ ꯍꯥꯌꯕ ꯍꯣꯡꯍꯟꯕ ꯌꯥꯏ; ꯑꯍꯦꯟꯕ ꯊꯤꯅꯕ ꯑꯃꯁꯨꯡ ꯃꯇꯨꯡꯒꯤ ꯅꯤꯠꯇꯕ ꯑꯐꯕ ꯑꯗꯨ ꯈꯛꯇꯃꯛ ꯌꯦꯡꯕ ꯃꯊꯧ ꯇꯥꯏ꯫ ꯀꯦꯐꯤꯟ ꯅꯠꯇ꯭ꯔꯒ ꯒꯦꯝ ꯑꯃꯅ ꯅꯪꯕꯨ ꯃꯤꯑꯣꯏ ꯄꯨꯝꯅꯃꯛꯀꯤ ꯃꯇꯝꯗꯥ ꯑꯔꯣꯏꯕ ꯍꯦꯟꯅ ꯊꯤꯅꯍꯜꯂꯤ ꯍꯥꯌꯕ ꯑꯐꯥꯎꯕ ꯄꯔꯤꯛꯁꯥ ꯑꯃꯠꯇ ꯂꯩꯇꯦ꯫ McLellan et al., 2016 Gardiner et al., 2023